Noted for MET gene amplification and high MET protein expression
Demonstrates invasive and motile behavior, ideal for metastasis modeling
Commonly used in targeted therapy screening against MET inhibitors
Often contrasted with other MET-high gastric or lung cancer lines for drug response studies
Description
The HS746T/JAK-Stat Pathway Firefly luciferase Reporter stable cell line, originating from a poorly differentiated gastric adenocarcinoma, is renowned for its MET gene amplification and high MET protein expression. It displays invasive and motile behavior, making it ideal for metastasis modeling. This cell line is commonly employed in gastric cancer research, particularly in studies focusing on MET signaling, drug resistance, and tumor invasiveness.
