The 2B8-CP070 monoclonal antibody is a recombinant, species-matched version of the original 2B8 antibody, with identical variable domains but a switched constant region from Rat IgG2b, κ to Mouse IgG2a, κ, designed for use in murine models. These antibodies exhibit regulated effector functions, reduced immunogenicity, and less formation of anti-drug antibodies (ADAs) compared to xenogenic antibodies. The controlled sequence and lack of genetic drift in recombinant antibodies ensure more reliable and reproducible results than hybridoma-derived antibodies.