Molecular weight approximately 12 kDa under reducing conditions
Human TGF-β1 shares 100% amino acid identity
Mouse TGF-β1 shares 99% amino acid identity
Mature human TGF-β1 identical to pig, dog, and cow TGF-β1
Mouse, rat, and horse TGF-β1 share 99% amino acid identity with human
Key regulator in diverse biological processes across many tissues and cell types
TGF-β1 inhibits growth factor and oncogene-induced transin/stromelysin
Activity measured by inhibiting IL-4-dependent HT2 mouse T cell proliferation
Effective dose range: 0.04-0.2 ng/mL
Recombinant Human TGF-β1 specific activity: approximately 2.5 × 10^4 U/μg
Endotoxin level: < 0.1 EU per 1μg of protein (LAL method)
Lyophilized from 0.2 μm filtered, concentrated solution in 35% Acetonitrile and 0.1% TFA
Description
Transforming growth factor beta 1 (TGF-β1), a significant pluripotent cytokine, exhibits a notable immunosuppressive effect. It's one of three closely related mammalian members of the expansive TGF-β superfamily, sharing a distinctive cystine knot structure. Mature human TGF-β1 shares 100% amino acid identity with pig, dog, and cow TGF-β1, and 99% with mouse, rat, and horse TGF-β1. TGF-β1 is a crucial regulator of various biological processes across many tissues and cell types, acting as a tumor suppressor via Smad-mediated signaling. It inhibits the growth factor and oncogene induction of transin/stromelysin, a secreted matrix-degrading metalloprotease.
