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Human DR5 Mouse IgG2a Fc من AB Biosciences in Saudi Arabia

Human DR5 Mouse IgG2a Fc من AB Biosciences

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مميزات خاصة

  • Species: Human
  • Protein Tag: Mouse IgG2a
  • Fc Type: Wildtype Fc
  • DR5 overexpression in 293T cells induces apoptosis-like changes
  • DR5's apoptotic capability and signalling pathway are debated
  • DR4 and DR5 appear functionally similar, with no distinct tissue involvement
  • Potential additional, unique signalling functions for DR4 and DR5

وصف

DR5, also known as TRAIL-R2, was discovered by two groups from EST data by seeking homologs of the TNFR1 death domain or the DR4 cysteine-rich domain (CRD). Two variants were found, one with a membrane proximal TAPE motif insertion. Like DR4, DR5's expression is broad. Unlike DR4, only one 4.4 kb transcript was detected. Similar to DR4, DR5 has a long signal peptide (51 amino acids), a CRD domain, and a death domain closely related to DR4.

منتجات شبيهه

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