Enclomiphene Citrate is a specific isomer of clomid, an organically synthesized research chemical that was deisgned to counter hypogonadism in males. Enclomiphene works by blocking estrogen receptors in the hypothalamus. This interference leads to an increase in the release of gonadotropin-releasing hormone (GnRH), which stimulates the pituitary to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH).