Heat sealing offers a 100% effective method for plate sealing for a complete seal integrity, as well as being quick and cost effective. Our Clear Heat Seal 3730 is an optically clear polyester backed film, forming a pierceable seal to polypropylene, polyethylene, polystyrene and cyclic olefin copolymer (COC) plates. The optical clarity of this seal enables its use for sealing plates required for imaging use, including fluorescent detection methods such as qPCR and colorimetric assays. Its pierceability renders it useful for automation and for use on needle, capillary and tip based liquid handling systems. It is effective on the ABI 3730 capillary sequencer, removing the need for the use of expensive septa mats.