Only new OTC Zegerid includes a patented, dual-ingredient formula: the leading prescription acid reducer (omeprazole). Plus a second ingredient (sodium bicarbonate) that protects the potent medicine from acid in the stomach, allowing the absorption of this omeprazole product. How can new zegerid OTC capsules benefit you? Contains a Proton Pump Inhibitor inch (ppi) – The only type of medicine specifically indicated to treat frequent heartburn. Just one capsule a day offers 24-hour relief from frequent heartburn. blocks the production of acid that causes frequent heartburn.