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Natural Hesperetin Product by Cayman Chemical in Saudi Arabia

Natural Hesperetin Product by Cayman Chemical

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Special Features

  • Decreases ApoB Protein Levels
  • Blocks IgG-Induced β-Hexosaminidase Release
  • Inhibits LPS-Induced Nitric Oxide Production
  • Reduces Neuronal Apoptosis in Cortex and Hippocampus
  • Decreases Body Weight Loss
  • Reduces Colon Shortening
  • Decreases Ulcer Severity
  • Reduces iNOS, IL-6, and IL-1β in BV-2 Microglial Cells
  • Reduces LPS-Induced Neuronal Inflammation in Mice
  • Reduces TNBS-Induced Ulcerative Colitis in Mice

Description

A flavonoid exhibiting diverse biological activities; it reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells at concentrations of 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); suppresses LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at a dose of 5 mg/kg; mitigates body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and enhances time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

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